COLTS 30, 49ERS 18

SANTA CLARA, Calif. — Carson Wentz threw two TD passes and ran for another score to lead Indianapolis to a rain-soaked victory over San Francisco.

The Colts (3-4) overcame the wet conditions and an early nine-point deficit to win for the third time in four games following an 0-3 start to the season.

The 49ers (2-4) dropped their fourth consecutive game and remained winless at home for more than a year since beating the Rams last Oct. 18, 2020, as the return of starting quarterback Jimmy Garoppolo failed to provide any spark on a wet night.

Garoppolo threw for 181 yards, lost a fumble, threw two interceptions and struggled to push the ball downfield in his first game back after missing one game with a calf injury.

Wentz and the Colts were able to do just enough on offense thanks to three pass interference penalties for 97 yards and a productive game on the ground from Jonathan Taylor, who ran for 107 yards and a score.

Wentz threw an 11-yard TD pass to Mo Alie-Cox in the first quarter and then led two short TD drives following fumbles by San Francisco, leading to his 1-yard score late in the first half and Taylor’s 5-yard run that made it 20-12 late in the third.